Research Highlights

How do bacteria build up natural products?

X-ray structure analysis gives detailed insights into molecular factory

[06.07.2020]The active agents of many drugs are natural products, so called because often only microorganisms are able to produce the complex structures. Similar to the production line in a factory, large enzyme complexes put these active agent molecules together. A team of the Technical University of Munich (TUM) and the Goethe University Frankfurt has now succeeded in investigating the basic mechanisms of one of these molecular factories. [mehr...]

Superatoms as catalysts

Prof. Roland Fischer awarded Reinhard Koselleck Project funding from the DFG

[30.04.2020] Precious metals like platinum are good catalysts – but they are expensive. While the chemical industry is trying to solve this cost issue by developing ever-smaller catalyst particles, a team from the Technical University of Munich (TUM) is taking an entirely new approach: the targeted development of catalyst particles from individual atoms. The Deutsche Forschungsgemeinschaft (DFG) is providing 1.2 million Euros in funding for this innovative work under the auspices of the Reinhard Koselleck Projects program. [more...]

Blocking sugar structures on viruses and tumor cells

Artificial sugar-binding protein may inhibit cell growth

[17.03.2020] During a viral infection, viruses enter the body and multiply in its cells. Viruses often specifically attach themselves to the sugar structures of the host cells, or present characteristic sugar structures on their surface themselves. Researchers at the Technical University of Munich (TUM) have developed a new type of protein reagent for identifying biological sugar structures, which may block the spread of an illness in the body if used for blocking the sugar structures of a cell or a pathogen. [more...]

Fatal overproduction of antibodies

Mutations in plasma cells play a key role in light chain amyloidosis

[10.03.2020] Using a mixture of oil droplets and hydrogel, medical active agents can be not only precisely dosed, but also continuously administered over periods of up to several days. The active agents inside the active droplets are released at a constant rate, decreasing the risk of over- or underdosage. [more...]

Active droplets

Long-lasting and precise dosing of medication thanks to an oil-hydrogel mixture

[20.02.2020] Using a mixture of oil droplets and hydrogel, medical active agents can be not only precisely dosed, but also continuously administered over periods of up to several days. The active agents inside the active droplets are released at a constant rate, decreasing the risk of over- or underdosage. [more...]

Guardian angel of the eye

Protective protein in the eye lens affects protein oxidation

[29.01.2020] The lens of the human eye comprises a highly concentrated protein solution, which lends the lens its great refractive power. Protective proteins prevent these proteins from clumping together throughout a lifetime. A team of scientists from the Technical University of Munich (TUM) has now uncovered the precise structure of the αA-crystallin protein and, in the process, discovered an important additional function. [more...]

A real alternative to crude oil

The synthesis of bio-based high-performance polyamide from biogenic residues

[27.01.2020] A research team from the Fraunhofer Society and the Technical University of Munich (TUM) led by chemist Volker Sieber has developed a new polyamide family which can be produced from a byproduct of cellulose production – a successful example for a more sustainable economy with bio-based materials.[more...]