Biochemistry / Protein science

Protein science represents an area of central importance at the Department of Chemistry. The research focuses on the function, structure and dynamics of proteins which is matched by small molecules interacting with proteins and modulating their properties. In the context of chemical biology a broad set of methods including chemical synthesis is used to answer complex biological questions. Due to the rapid development and groundbreaking innovations in these areas, the pace of novel discoveries with implications for biology, biochemistry and medicine, including pharmacological intervention is steadily increasing.

Cutting edge techniques at the department used include advanced solution and solid-state NMR methods in the Bavarian NMR center (Sattler, Kessler, Reif, Glaser, Dames, Madl), X-ray crystallography (Groll, Schneider), proteomics and mass-spectrometry (Sieber), Small Angle X-ray Scattering (Sattler, Madl, Buchner), electron microscopy (Weinkauf), biophysical and biochemical methods to study folding  and modifications (Buchner, ItzenWinter, Richter) as well as the chemical  synthesis of complex compounds  (Bach, Sieber, Hintermann, Tiefenbacher).

These research activities are embedded in the Center for integrated Protein Science excellence cluster (CIPSM) and two collaborative research centers (SFB 1035 and 749).