Dr. Oliver Lange
Organic Chemistry, Computational Structural Biology
Theoretische Strukturbiologie, NMR-Spektroskopie
We are interested in understanding the basic principles that govern conformational motion to enable a rational modulation of dynamic behavior of engineered biomolecules such as artificial enzymes and inhibitors.
As a stepping stone we strive to rationally design simple model systems that undergo specific conformational changes. To detect and characterize conformational changes we use Nuclear Magnetic Resonance (NMR) Spectroscopy. We will also continue our effort to develop computational tools to determine structure and dynamics of proteins with the help of sparse NMR data.