Research Areas

How do cells control that the proteins they produce possess the correct structure? How is it ensured that defective proteins are recognized and degraded instead of having potentially harmful effects on the organism? Which molecules and mechanisms underlie this molecular quality control? Professor M. Feige (b. 1979) addresses these questions with a particular focus on both secretory and membrane proteins. These protein classes play an important role in the interaction of cells with their environment, e.g. in the human immune system. In Professor Feige’s lab for Cellular Protein Biochemistry a particular emphasis is laid on proteins of direct medical relevance so that insights into the principles of cellular quality control might ultimately be translated into new biomedical and biotechnological applications.